UPDATE: As of 8:30 p.m., all but one left lane has reopened.
The Jacksonville Fire and Rescue Department told Action News Jax that two adults with life-threatening injuries and two pediatric patients with non-life-threatening injuries were transported from the scene.
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The Florida Highway Patrol reported the crash at 7 p.m. on Sunday. All northbound lanes of I-295E at Alta Drive were then closed.
A highway camera on FL511 shows a flipped vehicle and several emergency crews responding.
This story will be updated as more information becomes available.
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